Impact of ascorbic acid in reducing the incidence of vancomycin associated nephrotoxicity in critically ill patients: A preliminary randomized controlled trial

Name	World Continuing Education Alliance
Activity Title	Impact of ascorbic acid in reducing the incidence of vancomycin associated nephrotoxicity in critically ill patients: A preliminary randomized controlled trial
Details	Vancomycin (a glycopeptide antibiotic) has been the first line of treatment for methicillin-resistant. Trough level between 15–20 mg/L was recommended in complicated infections caused by. The incidence of vancomycin associated nephrotoxicity (VAN) is high and may reach 10–20% upon administering the conventional dose of vancomycin (one gram every 12 hours) and 30–40% upon administering the high dose (15–20 mg/kg every 8–12 hours).. Many risk factors have been found to increase the risk of VAN such as long duration of treatment (> seven days),. Oxidative stress has been thought to be the main cause of nephrotoxicity associated with vancomycin. The reactive oxygen species (ROS) generated by the mitochondria initiate renal cell apoptosis, which results in renal dysfunction.. The belief that oxidative stress plays a role in renal dysfunction has led to the concept that antioxidants can be beneficial in a nephro-protection approach. Ascorbic acid is an antioxidant that acts as a free radical... Objectives Course Objective Antioxidants show nephroprotective effect against vancomycin associated nephrotoxicity (VAN) in animals. This study aimed to assess the ascorbic acid nephro-protective role against VAN clinically.. Forty-one critically ill patients were randomly assigned to one of two groups: intervention group (vancomycin IV plus ascorbic acid, n=21) or control group (vancomycin IV only, n=20). Primary outcomes were the incidence of VAN and the absolute change in creatinine parameters, while mortality rate was the secondary outcome. Nephrotoxicity was defined as an increase in serum creatinine (S.cr) by at least 0.5 mg/dL or 50% of baseline.
Competence	General Medicine
Start Date	<span class="not-set">(not set)</span>
End Date	<span class="not-set">(not set)</span>
Event Time	03:15 PM
Location	World Continuing Education Alliance eLearning System
Cost (UGX)	0
CPD Points	1