Peptide arrays incubated with three collections of human sera from patients infected with mosquito-borne viruses

Name	World Continuing Education Alliance
Activity Title	Peptide arrays incubated with three collections of human sera from patients infected with mosquito-borne viruses
Details	Zika virus (ZIKV) is an arbovirus within the. The sequence similarity at the amino acid level in many flavivirus immunogenic protein regions contributes to the observed cross-reactivity in serological assays, which is especially high in the E protein and also present in the NS1 protein. Recent efforts to generate whole-genome sequences for these pathogens enable the application of bioinformatics tools to mine the data for trends and patterns that can be clinically applicable. The aim of current study is to evaluate the previously-predicted 15-mer viral peptides for their ability to act as differentiating B-cell epitopes, through high-throughput peptide arrays using relevant sera. We have recently completed an analysis of 137 serum samples using custom peptide arrays (each containing 866 experimental viral peptides) to identify 15-mer linear peptides that could be useful as serodiagnostic reagents to detect prior infection with mosquito-borne viruses. Specifically, we tested peptides re...
Competence	Public Health
Start Date	<span class="not-set">(not set)</span>
End Date	<span class="not-set">(not set)</span>
Event Time	02:45 PM
Location	World Continuing Education Alliance eLearning System
Cost (UGX)	0
CPD Points	1