| Details | CME SESSION: NEONATAL SEPTICAEMIA FOR HEALTH WORKERS
Introduction
Definition of Neonatal Septicaemia
Importance and relevance
Epidemiology and global burden
Pathophysiology
Pathogens involved (bacteria, viruses, fungi)
Routes of infection (vertical, horizontal)
Immune response in neonates
Risk Factors
Prematurity and low birth weight
Maternal infections
Breaks in sterile procedures
Invasive procedures
Clinical Features
Early-onset signs (within 72 hours): temperature instability, lethargy, irritability, poor feeding
Late-onset signs: respiratory distress, jaundice, seizures, hypotension
Challenges in clinical diagnosis
Diagnosis
History and physical examination
Laboratory investigations:
Blood culture
Complete blood count (CBC)
C-reactive protein (CRP)
Blood glucose
Lumbar puncture (if indicated)
Limitations and challenges
Management
Empirical antibiotic therapy
Supportive care:
Oxygen therapy
Fluid management
Thermoregulation
Monitoring and follow-up
Prevention
Maternal health and screening
Aseptic techniques during delivery and care
Early recognition and prompt management
Vaccination and prophylaxis where applicable
Role of Health Workers
Early detection and timely referral
Infection control practices
Parental education and counselling
Record keeping and reporting cases
Case Studies and Interactive Discussion
Real-life scenarios
Challenges faced in different settings
Summary and Take-home Messages
Key points to remember
Emphasis on prevention and early intervention
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