Non-AIDS defining malignancies in the combination ART era: immunological and socio-behavioral risk factors

About this activity

In high-income countries, life expectancy of people living with HIV (PLWHIV) on combination antiretroviral therapy (cART) is approaching that of the general population. An analysis of causes of death in the Data collection on Adverse events of Anti-HIV Drugs (a collaboration of eleven HIV cohort studies from Europe, the USA and Australia), found that mortality decreased from 1999 to 2011 for most causes of death, including AIDS-related, liver-related, cardiovascular and other or unknown causes. Several factors contribute to the higher risk of NADM among HIV-positive individuals, including prolonged exposure to immunodeficiency, a higher prevalence of smoking, and infections with oncogenic viruses such as human papilloma virus (HPV) or hepatitis B (HBV) or hepatitis C (HCV) viruses. We linked the database of the Swiss HIV Cohort Study (SHCS) with cantonal cancer registries to examine the relative importance of different risk factors for NADM, including immunological, virological and soc...