Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana

About this activity

Malaria remains a major global health concern especially in sub Saharan Africa.. The use of antimalarial drugs for malaria treatment and prevention has played an integral role in the control of the disease over the decades (. Point mutations in specific genes in the parasite genome are implicated in resistance to specific antimalarial drugs (. resistance to Sulfadoxine-pyrimethamine (SP) has been linked to point mutations in the bifunctional dihydrofolate reductase-thymidylate synthase (. In Ghana, prior to the withdrawal of CQ a prevalence range of between 46%–98% of the mutant. This study sought to ascertain the population trends in the prevalence of known drug-resistance-related point mutations in n Objectives Course Objective The emergence and spread of resistance in. To examine the prevalence of molecular markers associated with CQ and antifolate drug resistance in Ghana, we employed restriction fragment length polymorphism polymerase chain reaction to genotype and compare single nucleotide polymorphisms (SNPs) in the.