A Method to adjust for measurement error in multiple exposure variables measured with correlated errors in the absence of an internal validation study

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HIV: Human immunodeficiency virus; HBCT: Home-based HIV counseling and testing; HSRC: Human sciences research council; NCD: Non-communicable diseases; BMI: Body mass index; kg: kilogram; n Objectives Course Objective Difficulty in obtaining the correct measurement for an individual’s longterm exposure is a major challenge in epidemiological studies that investigate the association between exposures and health outcomes. Measurement error in an exposure biases the association between the exposure and a disease outcome. Usually, an internal validation study is required to adjust for exposure measurement error; it is challenging if such a study is not available. We propose a general method for adjusting for measurement error where multiple exposures are measured with correlated errors (a multivariate method) and illustrate the method using real data.