Candida antifungal drug resistance in sub-Saharan African populations: A systematic review

About this activity

species are known to shift from commensal to opportunistic infectious agents when triggered by factors such as immunosuppression, continuous usage of antibiotics and poor nutrition, leading to increased patient morbidity and mortality. Various antifungal drugs with different modes of action have been developed over the years. These include polyene antifungals (e.g. nystatin and amphotericin B), which interfere with ergosterol synthesis, thereby causing cell membrane leakage;