Coronavirus disease 2019 drug discovery through molecular docking

About this activity

Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that is responsible for respiratory illness and probably many more is yet to be discovered. This novel virus was first identified on 30. Then, it is necessary for the rapid development and approval of a vaccine, which is not yet available. The transmission of this coronavirus occurs due to the binding of the CoV spike protein to the angiotensin converting enzyme 2 (ACE2) receptor present on the cell surface of the human host. The ACE2 receptor is present in the respiratory organs, kidneys, gastrointestinal tract (at high levels in the esophagus, colon, and small intestine, but low in the stomach), and testes. Virulence of this novel virus is due to the presence of main protease responsible for virus replication along with many major functions. SARS-CoV-2 (negatively stained) when observed under the electron micrograph was found to be spherical in shape with some pleiomorph...